YK-8S

• Description:

  YK-8S is a dual-targeted K-Ras (G12D/G12C) covalent inhibitor. YK-8S shows no significant binding to wild-type K-Ras and other mutants (G12R, G13D, Q61R/K) . YK-8S exhibits anti-proliferative activity against H358 (G12C) and AGS (G12D) cells. YK-8S inhibits the phosphorylation of p-AKT/p-ERK in BaF3/G12D and G12C cells. YK-8S can be used for pancreatic cancer, colorectal cancer and other tumors with high incidence of G12D[1].

• UNSPSC:

  12352005

• Target:

  Akt; ERK; Ras

• Related Pathways:

  GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt

• Field of Research:

  Cancer

• Purity:

  87.47

• Smiles:

  FC1=C(C2=C(C=C1)C=CC=C2C3=C(C4=C(C=N3)C(N5CCN(CC5)C([C@H]6OC6)=O)=NC(OC[C@]78C[C@H](CN7CCC8)F)=N4)F)C#C

• Molecular Formula:

  C34H31F3N6O3

• Molecular Weight:

  628.64

• References & Citations:

  [1]Yu Z, et al. Simultaneous Covalent Modification of K-Ras (G12D) and K-Ras (G12C) with Tunable Oxirane Electrophiles. J Am Chem Soc. 2023 Sep 20;145 (37) :20403-20411.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Akt; ERK; K-Ras

• CAS Number:

  [3060515-08-1]