YK-8S

CAT: 0804-HY-159591Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-159591Size:1 Each
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Description
YK-8S is a dual-targeted K-Ras (G12D/G12C) covalent inhibitor. YK-8S shows no significant binding to wild-type K-Ras and other mutants (G12R, G13D, Q61R/K) . YK-8S exhibits anti-proliferative activity against H358 (G12C) and AGS (G12D) cells. YK-8S inhibits the phosphorylation of p-AKT/p-ERK in BaF3/G12D and G12C cells. YK-8S can be used for pancreatic cancer, colorectal cancer and other tumors with high incidence of G12D[1].
CAS Number
[3060515-08-1]
UNSPSC
12352005
Target
Akt; ERK; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer
Purity
87.47
Smiles
FC1=C(C2=C(C=C1)C=CC=C2C3=C(C4=C(C=N3)C(N5CCN(CC5)C([C@H]6OC6)=O)=NC(OC[C@]78C[C@H](CN7CCC8)F)=N4)F)C#C
Molecular Formula
C34H31F3N6O3
Molecular Weight
628.64
References & Citations
[1]Yu Z, et al. Simultaneous Covalent Modification of K-Ras (G12D) and K-Ras (G12C) with Tunable Oxirane Electrophiles. J Am Chem Soc. 2023 Sep 20;145 (37) :20403-20411.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt; ERK; K-Ras

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