YK-2-69

• Description :

  YK-2-69 is a highly selective DYRK2 inhibitor with an IC50 value of 9 nM. YK-2-69 specifically interacts with Lys-231 and Lys-234 of DYRK2 and can be utilized in researches related to prostate cancer[1].

• UNSPSC :

  12352005

• Target :

  DYRK

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/yk-2-69.html

• Purity :

  99.57

• Solubility :

  DMSO : 5.83 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(N1CCN(CC1)CC)C2=CN=C(NC3=NC(C4=CC5=C(N=C(N(C)C)S5)C=C4)=C(F)C=N3)C=C2

• Molecular Formula :

  C25H27FN8OS

• Molecular Weight :

  506.60

• References & Citations :

  [1]Yuan K, et al. Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer. Nat Commun. 2022 May 25;13 (1) :2903.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  DYRK2

• CAS Number :

  [2619846-89-6]