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YK-4-279

CAT: 0804-HY-14507-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14507-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein) . YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer[1][2].
CAS Number
1037184-44-3
UNSPSC
12352005
Hazard Statement
H302, H317
Target
Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/YK-4-279.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
ClC1=C2C(C(O)(CC(C3=CC=C(OC)C=C3)=O)C(N2)=O)=C(Cl)C=C1
Molecular Formula
C17H13Cl2NO4
Molecular Weight
366.20
Precautions
H302, H317
References & Citations
[1]Erkizan HV, et al. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. Nat Med. 2009 Jul;15 (7) :750-6.|[2]Barber-Rotenberg JS, et al. Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. Oncotarget. 2012 Feb;3 (2) :172-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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