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Complex 3

CAT: 0804-HY-158726Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158726Size:1 Each
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Description
Complex 3 is a fluorescent dithiocarbazate-copper complex with anticancer activity, which localizes to mitochondria. Complex 3 displays excitation/emission maxima of 455-495/535 nm, respectively. Complex 3 inhibits the growth of BxPC-3, AsPC-1, PANC-1, and WI38 pancreatic cancer cells with IC50 values of 0.74, 0.41, 0.62, and 2.06 µM, respectively. Complex 3 induces lipid peroxidation and mitochondrial rupture and shrinkage in AsPC-1 cells. Complex 3 also induces mitochondrial apoptosis and cytokine-cytokine receptor interaction dysfunction in AsPC-1 cells. Complex 3 reduces tumor volume in an AsPC-1 mouse xenograft model[1].
CAS Number
2480150-28-3
UNSPSC
12352005
Target
Apoptosis; Fluorescent Dye
Related Pathways
Apoptosis; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
[Br-][Cu+2]1([S-]2)[N](N=C2SC)=C(C3=CC=CC=[N]3[Cu+]([N]4=CC=CC=C4C(C5=CC=CC=[N]56)=[N](N=C7SC)[Cu+2]6([S-]7)[Br-])[Br-])C8=CC=CC=[N]81
Molecular Formula
C26H22Br3Cu3N8S4
Molecular Weight
1005.12
References & Citations
[1]Gou Y, et al. Dithiocarbazate-Copper Complexes for Bioimaging and Treatment of Pancreatic Cancer. J Med Chem. 2021 May 13;64 (9) :5485-5499.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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