Complex 3

• Description :

  Complex 3 is a fluorescent dithiocarbazate-copper complex with anticancer activity, which localizes to mitochondria. Complex 3 displays excitation/emission maxima of 455-495/535 nm, respectively. Complex 3 inhibits the growth of BxPC-3, AsPC-1, PANC-1, and WI38 pancreatic cancer cells with IC50 values of 0.74, 0.41, 0.62, and 2.06 µM, respectively. Complex 3 induces lipid peroxidation and mitochondrial rupture and shrinkage in AsPC-1 cells. Complex 3 also induces mitochondrial apoptosis and cytokine-cytokine receptor interaction dysfunction in AsPC-1 cells. Complex 3 reduces tumor volume in an AsPC-1 mouse xenograft model[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Fluorescent Dye

• Related Pathways :

  Apoptosis; Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  [Br-][Cu+2]1([S-]2)[N](N=C2SC)=C(C3=CC=CC=[N]3[Cu+]([N]4=CC=CC=C4C(C5=CC=CC=[N]56)=[N](N=C7SC)[Cu+2]6([S-]7)[Br-])[Br-])C8=CC=CC=[N]81

• Molecular Formula :

  C26H22Br3Cu3N8S4

• Molecular Weight :

  1005.12

• References & Citations :

  [1]Gou Y, et al. Dithiocarbazate-Copper Complexes for Bioimaging and Treatment of Pancreatic Cancer. J Med Chem. 2021 May 13;64 (9) :5485-5499.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [2480150-28-3]