PF-04455242

CAT: 0804-HY-15691Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-15691Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

PF-04455242 is a high-affinity, selective κ-opioid receptor antagonist, with an average Ki value of 3.0 nM for human κ-opioid receptor. PF-04455242 blocks analgesia. PF-04455242 demonstrates antidepressant-like efficacy, attenuates the behavioral effects of stress[1].

CAS Number

1202647-54-8

UNSPSC

12352005

Target

Opioid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=S(C1=CC=CC=C1C2=CC=C(CNCC(C)C)C=C2)(N3CCCC3)=O

Molecular Formula

C21H28N2O2S

Molecular Weight

372.52

References & Citations

[1]Grimwood S, et al. Pharmacological characterization of 2-methyl-N- ((2'- (pyrrolidin-1-ylsulfonyl) biphenyl-4-yl) methyl) propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ-opioid receptors. J Pharmacol Exp Ther. 2011 Nov;339 (2) :555-66.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

κ Opioid Receptor/KOR

Related Products

Catalog	Name
HY-P990649-01	PF-5212374
HY-111965-01	PF-06647263
HY-10459-01	PF-562271
HY-108341-01	PF-06424439
HY-100398-01	PF-04979064
HY-131972-01	PF-06843195
HY-14464-01	PF-00489791
HY-121163-01	PF-184563
HY-124947	PF-4522654
HY-116524	PF-04781340

Alternative Products

Catalog	Name
GTR19259591-01	PF-04455242
GTR19259602-01	PF-04455242 hydrochloride
MBS579460	PF-03084014 (PF-3084014)
M36412-01	PF-17
M34376-01	PF-184298
M33060-01	PF-04957325
M28021-01	PF-1355
M26783-01	PF-04937319
M26368-01	PF-04885614
M24156-01	PF-9363

PF-04455242

Related Products

Alternative Products

Popular Products