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TLD-1433

CAT: 0804-HY-156786Size: 1 EachDry Ice: NoHazardous: No
CAT#: HY-156786Size: 1 Each
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TLD-1433 is the fourth-generation ruthenium (II) based photodynamic compound (PDC) . TLD-1433 is activated by green light (525 ± 25 nm) and efficiently generates ROS to achieve pathogen inactivation. After photoinactivation, TLD-1433 significantly induces lipid peroxidation of the cell membrane, which can directly damage the integrity of the viral envelope. TLD-1433 has ID50 for enveloped viruses (such as H1N1 influenza virus, coronavirus OC43, HSV-1, Zika virus) is as low as nanomolar level; for non-enveloped viruses (such as adenovirus Ad5, mammalian rotavirus MRV), a concentration of micro-molar level is required for inactivation. TLD-1433 has antigen retention property and can be used for the preparation of inactivated vaccines[1].
CAS Number
[1471479-22-7]
UNSPSC
12352005
Target
HSV; Influenza Virus; Reactive Oxygen Species (ROS) ; SARS-CoV
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Infection
Smiles
CC1=CC=[N](C2=C1)[Ru+2]([N]3=CC=C4)([N](C5=C6)=CC=C6C)([N](C5=C7)=CC=C7C)([N](C2=C8)=CC=C8C)[N]9=CC=CC%10=C9C3=C4C%11=C%10NC(C%12=CC=C(C%13=CC=C(C%14=CC=CS%14)S%13)S%12)=N%11.[Cl-].[Cl-]
Molecular Formula
C49H38Cl2N8RuS3
Molecular Weight
1007.05
References & Citations
[1]Coombs KM, et al. Nanomolar concentrations of the photodynamic compound TLD-1433 effectively inactivate numerous human pathogenic viruses. Heliyon. 2024 May 29;10 (11) :e32140.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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