MSI-1436

• Description :

  MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of appr 1 μM, 200-fold preference over TCPTP (IC50, 224 μM) .

• Product Name Alternative :

  Trodusquemine; Aminosterol-1436

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Phosphatase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/MSI-1436.html

• Purity :

  95.0

• Solubility :

  10 mM in DMSO

• Smiles :

  NCCCNCCCCNCCCN[C@@H]1C[C@@](C[C@@H](O)[C@]2([H])[C@]3([H])CC[C@@]4(C)[C@@]2([H])CC[C@@]4([C@H](C)CC[C@@H](OS(=O)(O)=O)C(C)C)[H])([H])[C@]3(C)CC1

• Molecular Formula :

  C37H72N4O5S

• Molecular Weight :

  685.06

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Lantz KA, et al. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring) . 2010 Aug;18 (8) :1516-1523.|[2]Qin Z, et al. Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling. Neuron. 2015 Mar 18;85 (6) :1319-31.|[3]Qin Z, et al. Functional properties of Claramine: a novel PTP1B inhibitor and insulin-mimetic compound. Biochem Biophys Res Commun. 2015 Feb 27;458 (1) :21-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Citation 01 :

  Exp Neurol. 2025 Mar:385:115115.|J Leukoc Biol. 2024 Jul 16:qiae159.|Spectrochim Acta A Mol Biomol Spectrosc. 2024 Nov 3:327:125394.|Commun Biol. 2021 Feb 24;4 (1) :248.|J Ginseng Res. 2025 Sep 2.|Nature. 2024 Jul;631 (8020) :415-423.|Oncol Rep. 2024 Nov;52 (5) :149.

• CAS Number :

  [186139-09-3]