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20:4 Lyso PI

CAT: 0804-HY-150187Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150187Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
20:4 Lyso PI is a selective G protein-coupled receptor GPR55 agonist. 20:4 Lyso PI triggers cell rounding in GPR55-expressing HEK293 cells, with an EC50 value of 10 nM. 20:4 Lyso PI promotes RhoA activation and subsequent ROCK-dependent cytoskeletal rearrangement. 20:4 Lyso PI activates the ERK signaling pathway and elevates intracellular free calcium. 20:4 Lyso PI can be used for the study of immune diseases[1].
CAS Number
1246430-04-5
UNSPSC
12352211
Target
Calcium Channel; ERK; GPR55
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
O[C@H]1[C@@H](OP(O)(OC[C@@H](COC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)O)=O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O
Molecular Formula
C29H49O12P
Molecular Weight
620.67
References & Citations
[1]Nakajima K, et al. Lysophosphatidylinositol Induced Morphological Changes and Stress Fiber Formation through the GPR55-RhoA-ROCK Pathway. Int J Mol Sci. 2022 Sep 18;23 (18) :10932.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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