NDI-Lyso

CAT: 0804-HY-P10669Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P10669Size:1 Each
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Description
NDI-Lyso is a lysosome-targeted anticancer agent that induces the formation of rigid long fibers in cancer cell lysosomes through an enzyme-instructed self-assembly (EISA) mechanism catalyzed by cathepsin B. This process triggers lysosomal swelling, membrane permeabilization (LMP), and membrane disruption, ultimately leading to cancer cell apoptosis via a non-classical caspase-independent pathway. NDI-Lyso exhibits significant selective anticancer activity in various cancer cell lines and drug-resistant cancer cells (IC50 ~10 μM) while showing low toxicity to normal cells (IC50 > 60 μM) [1].
CAS Number
[2999646-19-2]
UNSPSC
12352209
Target
Apoptosis; Caspase
Type
Peptides
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ndi-lyso.html
Smiles
O=C(C1=CC=C2C3=C1C4=CC=C3C(N(CCCCCC)C2=O)=O)N(CCC(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)C4=O
Molecular Formula
C71H100N22O13
Molecular Weight
1469.69
References & Citations
[1]Jana B, et al. Intra-Lysosomal Peptide Assembly for the High Selectivity Index against Cancer. J Am Chem Soc. 2023 Aug 23;145 (33) :18414-18431.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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