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LP-661438

CAT: 0804-HY-14509Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14509Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LP-661438 (Compound 10) is an orally active DCK inhibitor (IC50 = 1.7 nM) . LP-661438 inhibits deoxycytidine kinase in T cells and in vivo[1].
CAS Number
1034174-88-3
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Smiles
O=C(N[C@H]1CC[C@H](N2C(N=C(N)C(F)=C2)=O)C1)C3=NC=CC(C4=CC5=CC=CC=C5S4)=C3
Molecular Formula
C23H20FN5O2S
Molecular Weight
449.50
References & Citations
[1]Jessop TC, et al. Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19 (23) :6784-7. d
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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