LP-661438

• Description:

  LP-661438 (Compound 10) is an orally active DCK inhibitor (IC50 = 1.7 nM) . LP-661438 inhibits deoxycytidine kinase in T cells and in vivo[1].

• UNSPSC:

  12352005

• Target:

  DNA/RNA Synthesis

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C(N[C@H]1CC[C@H](N2C(N=C(N)C(F)=C2)=O)C1)C3=NC=CC(C4=CC5=CC=CC=C5S4)=C3

• Molecular Formula:

  C23H20FN5O2S

• Molecular Weight:

  449.50

• References & Citations:

  [1]Jessop TC, et al. Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19 (23) :6784-7. d

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1034174-88-3]