MK-5757

• Description :

  MK-5757 is a Nociceptin/Orphanin FQ Peptide Receptor antagonist. ORL1 antagonist 3 can improve cerebral blood flow disorders and ischemic damage, and alleviate abnormal neurological symptoms. ORL1 antagonist 3can be used for the research of neurological disease, such as traumatic brain injury[1].

• UNSPSC :

  12352005

• Target :

  Opioid Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  [H][C@]1(CC2)C[C@]2([H])C3(CC3)[C@H]1CN4CCC(N5C6=CC=CC=C6N(C5=O)C[C@@H](O)CO)CC4

• Molecular Formula :

  C25H35N3O3

• Molecular Weight :

  425.56

• References & Citations :

  [1]Identification of an Orally Active Opioid Receptor-like 1 (ORL1) Receptor Antagonist 4-{3-[ (2R) -2,3-Dihydroxypropyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-[ (1S,3S,4R) -spiro[bicyclo[2.2.1]heptane-2,1′-cyclopropan]-3-ylmethyl]piperidine as Clinical Candidate J. Med. Chem., 2009, 52 (14), pp 4091-4094|[2]Kelly M. Standifer, et al. Methods of treating traumatic brain injury and related neurological conditions. US20240252585 A1. 2024-08-01

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NOP Receptor/ORL1

• CAS Number :

  [919482-44-3]