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KVA-D-88

CAT: 0804-HY-139178-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-139178-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KVA-D-88 is a blood-brain barrier-permeable PDE4 inhibitor with IC50 values of 140 and 880 nM for PDE4B and PDE4D, respectively. KVA-D-88 has the ability to inhibit cocaine-induced hyperlocomotor activity and sensitization. KVA-D-88 selectively inhibits PDE4B and reduces cAMP degradation, thereby modulating neuroadaptive responses. KVA-D-88 can be used in the study of cocaine addiction[1].
CAS Number
[2410550-31-9]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.81
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=CC=CN=C2N1C3=CC=C(Cl)C(Cl)=C3)N4CC(F)(F)C4
Molecular Formula
C17H11Cl2F2N3O
Molecular Weight
382.19
References & Citations
[1]Burkovetskaya ME, et al. KVA-D-88, a Novel Preferable Phosphodiesterase 4B Inhibitor, Decreases Cocaine-Mediated Reward Properties in Vivo. ACS Chem Neurosci. 2020 Aug 5;11 (15) :2231-2242.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4

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