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PF-06672131

CAT: 0804-HY-138916-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138916-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-06672131 is an alkynylated afatinib derivative and a small molecule probe that is reactive to cysteine. PF-06672131 is an inhibitor of epidermal growth factor receptor (EGFR) kinase that targets the ATP pockets of EGFR. PF-06672131 can be used for activity-based protein profiling studies[1].
CAS Number
1621002-27-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents; EGFR
Related Pathways
JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Others
Purity
99.47
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC#C)/C=C/CN(C)C
Molecular Formula
C23H21ClFN5O2
Molecular Weight
453.90
Precautions
H302, H315, H319, H335
References & Citations
[1]van Bergen W, et al. Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22 (1) :100455.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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