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8-Nitro-cGMP

CAT: 0804-HY-134314Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-134314Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
8-Nitro-cGMP is an electrophilic second messenger of redox signaling that can form a protein-S-cGMP adduct in s-guanylation process. 8-Nitro-cGMP is an autophagy inducer. 8-Nitro-cGMP promotes RANKL-induced osteoclast differentiation from macrophages. 8-Nitro-cGMP has vasodilator effect, and ameliorates the vascular endothelial dysfunction in diabetic mice[1][2][3][4].
CAS Number
[913645-39-3]
UNSPSC
12352005
Target
Autophagy; Endogenous Metabolite; Nucleoside Antimetabolite/Analog
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Smiles
O=C1C2=C(N([C@@H]3O[C@H](CO4)[C@@H](OP4(O)=O)[C@H]3O)C([N+]([O-])=O)=N2)NC(N)=N1
Molecular Formula
C10H11N6O9P
Molecular Weight
390.20
References & Citations
[1]Ihara H, et al. Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells. Chem Res Toxicol. 2017 Sep 18;30 (9) :1673-1684. |[2]Tokutomi Y, et al. Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice. Br J Pharmacol. 2011 Apr;162 (8) :1884-93. |[3]Kaneko K, et al. 8-Nitro-cGMP is a promoter of osteoclast differentiation induced by RANKL. Nitric Oxide. 2018 Jan 30;72:46-51.|[4]Rawet-Slobodkin M, Elazar Z. 8-nitro-cGMP--a new player in antibacterial autophagy. Mol Cell. 2013 Dec 26;52 (6) :767-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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