Dibutyryl-cGMP (sodium)

Dibutyryl-cGMP (sodium)

• Product Name Alternative: Bt2cGMP (sodium)
• CAS Number: 51116-00-8
• UNSPSC Description: Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analogue. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits the release of [3H]-arachidonic acid from γ thrombin-stimulated human platelets. Dibutyryl-cGMP sodium induces peripheral antinociception via activation of ATP-sensitive K+ channels[1][2][3].
• Target Antigen: Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/dibutyryl-cgmp-sodium.html
• Purity: 99.55
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
• Smiles: CCCC(NC1=NC2=C(C(N1)=O)N=CN2[C@H]3[C@@H]([C@H]4[C@H](O3)COP(O4)(O[Na])=O)OC(CCC)=O)=O
• Molecular Weight: 507.37
• References & Citations: [1]Borán MS, et al. The cyclic GMP-protein kinase G pathway regulates cytoskeleton dynamics and motility in astrocytes. J Neurochem. 2007 Jul;102(1):216-30.|[2]Sane DC, et al. Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets. Biochem Biophys Res Commun. 1989 Dec 15;165(2):708-14.|[3]Soares AC, et al. Dibutyryl-cyclic GMP induces peripheral antinociception via activation of ATP-sensitive K(+) channels in the rat PGE2-induced hyperalgesic paw. Br J Pharmacol. 2001 Sep;134(1):127-31.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, stored under nitrogen, away from moisture)
• Clinical Information: No Development Reported