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4-Hydroxy atorvastatin (hemicalcium)

CAT: 0804-HY-137310-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137310-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Hydroxy atorvastatin hemicalcium is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin[1][2].
CAS Number
265989-44-4
UNSPSC
12352005
Hazard Statement
H302
Target
Drug Metabolite; HMG-CoA Reductase (HMGCR)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Purity
96.19
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@@H](C[C@@H](O)CC(O)=O)CCN1C(C(C=C2)=CC=C2F)=C(C3=CC=CC=C3)C(C(NC(C=C4)=CC=C4O)=O)=C1C(C)C.[1/2].[Ca]
Molecular Formula
C33H35FN2O6.1/2Ca
Molecular Weight
594.68
Precautions
H302
References & Citations
[1]van Dam M, et al. Long term efficacy and safety of atorvastatin in the treatment of severe type III and combined dyslipidaemia. Heart. 2002;88 (3) :234-238. |[2]Diabetes Atorvastin Lipid Intervention (DALI) Study Group. The effect of aggressive versus standard lipid lowering by atorvastatin on diabetic dyslipidemia: the DALI study: a double-blind, randomized, placebo-controlled trial in patients with type 2 diabetes and diabetic dyslipidemia. Diabetes Care. 2001;24 (8) :1335-1341.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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TRC-H828961-10MG4-Hydroxy Atorvastatin Hemicalcium Salt
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