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4-Hydroxy Atorvastatin lactone

CAT: 0804-HY-126852Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126852Size:1 mg
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Description
4-Hydroxy Atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1].
CAS Number
163217-70-7
Product Name Alternative
P-Hydroxyatorvastatin lactone; 4-ATL
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/4-hydroxy-atorvastatin-lactone.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C(C)C)N(CC[C@@H]2C[C@@H](O)CC(O2)=O)C(C3=CC=C(F)C=C3)=C1C4=CC=CC=C4)NC5=CC=C(O)C=C5
Molecular Formula
C33H33FN2O5
Molecular Weight
556.62
Precautions
H302, H315, H319, H335
References & Citations
[1]Jemal M, et al. Quantitation of the acid and lactone forms of atorvastatin and its biotransformation products in human serum by high-performance liquid chromatography with electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom. 1999;13 (11) :1003-15.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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