IIIM-1270

CAT: 0804-HY-133133-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-133133-01Size:5 mg
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Description
IIIM-1270is a NLRP3 inflammasome inhibitor. IIIM-1270 inhibits IL-1β release in mouse macrophages (J774A.1 cells) (IC50 = 3.5 μM) and significantly reduced the protein expression level of mature IL-1β. IIIM-1270 can be used for the study of inflammation[1].
CAS Number
[4818-19-3]
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Purity
98.78
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC1=CC=C(/C=C2SC(NC/2=O)=O)C(C)=C1
Molecular Formula
C12H11NO2S
Molecular Weight
233.29
References & Citations
[1]Abdullaha M, et al. Discovery of benzo[cd]indol-2-one and benzylidene-thiazolidine-2,4-dione as new classes of NLRP3 inflammasome inhibitors via ER-β structure based virtual screening. Bioorg Chem. 2020 Jan;95:103500.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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