SR-1277

• UNSPSC Description:

  SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer[1].

• Target Antigen:

  Casein Kinase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sr-1277.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=[N+](C1=C2C(N=C(CNC3=C4N=CN(C5=CSC=C5)C4=NC(N6CCOCC6)=N3)N2)=CC=C1)[O-]

• Molecular Weight:

  477.50

• References & Citations:

  [1]Bibian M, et, al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1446715-47-4