SR-1277
CAT:
804-HY-108907
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
SR-1277
- CAS Number: 1446715-47-4
- UNSPSC Description: SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer[1].
- Target Antigen: Casein Kinase
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Stem Cell/Wnt
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/sr-1277.html
- Solubility: 10 mM in DMSO
- Smiles: O=[N+](C1=C2C(N=C(CNC3=C4N=CN(C5=CSC=C5)C4=NC(N6CCOCC6)=N3)N2)=CC=C1)[O-]
- Molecular Weight: 477.50
- References & Citations: [1]Bibian M, et, al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported