IIIM-8

• Description:

  IIIM-8 is a melanogenesis inhibitor. IIIM-8 inhibits pigment production both in vitro and in vivo without incurring any cytotoxicity in Human Adult Epidermal Melanocytes (HAEM) . IIIM-8 can be used for hyperpigmentation disorders research[1].

• UNSPSC:

  12352005

• Target:

  Melanocortin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/iiim-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=C(C(C)=O)C(O)=C(C2=CCN(C)CC2)C(O)=C1

• Molecular Formula:

  C14H17NO4

• Molecular Weight:

  263.29

• References & Citations:

  [1]Naikoo SH, et al. Inhibition of melanogenesis by 3- (1'-methyltetrahydropyridinyl) -2,4-6-trihydroxy acetophenone via suppressing the activity of cAMP response element-binding protein (CREB) and nuclear exclusion of CREB-regulated transcription coactivator 1 (CRTC1) . Eur J Pharmacol. 2023 Aug 5;952:175734.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1128053-62-2]