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GTx-027

CAT: 0804-HY-171048-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171048-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GTx-027 is an orally active and non-steroidal selective androgen receptor modulator (SARM) . GTx-027 shows androgen receptor (AR) transactivation effects with the EC50 of 1.8 nM. GTx-027 acts selectively increase muscle weight (anabolic) without affecting secondary sexual organs (androgenic) . GTx-027 has the protential for the study of breast cancer and stress urinary incontinence (SUI) [1][2].
CAS Number
928122-40-1
UNSPSC
12352005
Target
Androgen Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC(C=C1)=CC=C1OC[C@](C)(O)C(NC2=CC(Cl)=C(C=C2)C#N)=O
Molecular Formula
C18H14ClN3O3
Molecular Weight
355.78
References & Citations
[1]Suriyan Ponnusamy, et al. Tissue Selective Androgen Receptor Modulators (SARMs) Increase Pelvic Floor Muscle Mass in Ovariectomized Mice. J Cell Biochem. 2017 Mar;118 (3) :640-646.|[2]Narayanan R, et al. Selective androgen receptor modulators (SARMs) negatively regulate triple-negative breast cancer growth and epithelial:mesenchymal stem cell signaling. PLoS One. 2014 Jul 29;9 (7) :e103202.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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