PF-794

CAT: 0804-HY-122805-01Size: 5 mgDry Ice: YesHazardous: No
CAT#:0804-HY-122805-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-794 is a potent, selective and ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with an IC50 of 39 nM. PF-794 shows selective for the TNIK family. PF-794 reduces endogenous p120-catenin phosphorylation in cells. PF-794 can be used for teh study of psychiatric disorders[1].
CAS Number
[2056111-45-4]
UNSPSC
12352005
Target
Ser/Thr Protease
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.19
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C=C1)C2=CC(C3=CC=C(C=C3)C#N)=CN=C2N)NC(C)C
Molecular Formula
C22H20N4O
Molecular Weight
356.42
References & Citations
[1]Wang Q, et al. Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK. J Pharmacol Exp Ther. 2016 Feb;356 (2) :410-23.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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