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MLS-2384 (free base)

CAT: 0804-HY-125718Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-125718Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MLS-2384 free base is a dual JAK/Src kinase inhibitor. MLS-2384 free base downregulates STAT3 downstream proteins c-Myc and Mcl-1. MLS-2384 free base induces Apoptosis. MLS-2384 free base exhibits anticancer activity against prostate cancer, breast cancer, skin cancer, ovarian cancer, lung cancer, and liver cancer[1].
CAS Number
1067884-45-0
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; c-Myc; JAK; Src; STAT
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1NC2=C(C=CC(Br)=C2)/C1=C3NC4=C(C=CC=C4)C/3=N\OCCN5CCNCC5
Molecular Formula
C22H22BrN5O2
Molecular Weight
468.35
References & Citations
[1]Liu L, et al. MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells. Cancer Biol Ther. 2014 Feb;15 (2) :178-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Mcl-1; STAT3

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