5F-203 (Standard)

CAT: 0804-HY-124421R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-124421R-01Size:5 mg
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Description
5F-203 (Standard) is the analytical standard of 5F-203. This product is intended for research and analytical applications. 5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38[1][2][3].
CAS Number
[260443-89-8]
UNSPSC
12352100
Target
Aryl Hydrocarbon Receptor; Reference Standards
Related Pathways
Immunology/Inflammation; Others
Field of Research
Others
Smiles
NC1=CC=C(C2=NC3=CC(F)=CC=C3S2)C=C1C
Molecular Formula
C14H11FN2S
Molecular Weight
258.32
References & Citations
[1]Hutchinson I, et al. Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2- (4-aminophenyl) benzothiazole amino acid prodrugs. J Med Chem. 2002 Jan 31;45 (3) :744-7. |[2]Hose CD, et al. Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity. Mol Cancer Ther. 2003 Dec;2 (12) :1265-72.|[3]Callero MA, et al. Biomarkers of sensitivity to potent and selective antitumor 2- (4-amino-3-methylphenyl) -5-fluorobenzothiazole (5F203) in ovarian cancer. J Cell Biochem. 2013 Oct;114 (10) :2392-404.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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