CA-5f

• Description:

  CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; Atg8/LC3; Autophagy; p62

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/CA-5f.html

• Purity:

  99.14

• Solubility:

  DMSO : 77.5 mg/mL (ultrasonic)

• Smiles:

  O=C(/C(CN(C)C/1)=C/C2=CNC3=C2C=CC=C3)C1=C\C4=CC=C(OC)C(OC)=C4

• Molecular Formula:

  C24H24N2O3

• Molecular Weight:

  388.46

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Zhang L, et al. Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. Autophagy. 2019 Mar;15 (3) :391-406.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1370032-19-1]