CA-5f

CAT: 0804-HY-112698-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112698-01Size:1 mg
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Description
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity[1].
CAS Number
[1370032-19-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Atg8/LC3; Autophagy; p62
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CA-5f.html
Purity
99.14
Solubility
DMSO : 77.5 mg/mL (ultrasonic)
Smiles
O=C(/C(CN(C)C/1)=C/C2=CNC3=C2C=CC=C3)C1=C\C4=CC=C(OC)C(OC)=C4
Molecular Formula
C24H24N2O3
Molecular Weight
388.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang L, et al. Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. Autophagy. 2019 Mar;15 (3) :391-406.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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