5F-203

• Description:

  5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38[1][2][3].

• Product Name Alternative:

  NSC-703786

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Aryl Hydrocarbon Receptor

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/5f-203.html

• Purity:

  99.04

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  NC1=CC=C(C2=NC3=CC(F)=CC=C3S2)C=C1C

• Molecular Formula:

  C14H11FN2S

• Molecular Weight:

  258.32

• Precautions:

  H302

• References & Citations:

  [1]Hutchinson I, et al. Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2- (4-aminophenyl) benzothiazole amino acid prodrugs. J Med Chem. 2002 Jan 31;45 (3) :744-7. |[2]Hose CD, et al. Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity. Mol Cancer Ther. 2003 Dec;2 (12) :1265-72.|[3]Callero MA, et al. Biomarkers of sensitivity to potent and selective antitumor 2- (4-amino-3-methylphenyl) -5-fluorobenzothiazole (5F203) in ovarian cancer. J Cell Biochem. 2013 Oct;114 (10) :2392-404.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  260443-89-8