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5F-203

CAT: 0804-HY-124421-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124421-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38[1][2][3].
CAS Number
260443-89-8
Product Name Alternative
NSC-703786
UNSPSC
12352005
Hazard Statement
H302
Target
Aryl Hydrocarbon Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/5f-203.html
Purity
99.04
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=CC=C(C2=NC3=CC(F)=CC=C3S2)C=C1C
Molecular Formula
C14H11FN2S
Molecular Weight
258.32
Precautions
H302
References & Citations
[1]Hutchinson I, et al. Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2- (4-aminophenyl) benzothiazole amino acid prodrugs. J Med Chem. 2002 Jan 31;45 (3) :744-7. |[2]Hose CD, et al. Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity. Mol Cancer Ther. 2003 Dec;2 (12) :1265-72.|[3]Callero MA, et al. Biomarkers of sensitivity to potent and selective antitumor 2- (4-amino-3-methylphenyl) -5-fluorobenzothiazole (5F203) in ovarian cancer. J Cell Biochem. 2013 Oct;114 (10) :2392-404.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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KKA44389-015F-203
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A22708-100NSC-703786 (5F-203) 100mg
A22708-25NSC-703786 (5F-203) 25mg
A22708-10NSC-703786 (5F-203) 10mg
A22708-50NSC-703786 (5F-203) 50mg
A22708-5NSC-703786 (5F-203) 5mg
A22708-2NSC-703786 (5F-203) 2mg

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