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CGP-45688

CAT: 0804-HY-123500Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123500Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CGP-45688 is an orally active non-steroidal aromatase inhibitor with an ED50 of 30-100 μg/kg. CGP-45688 can reduce the level of estrogen in the body, thereby inhibiting the growth of estrogen-dependent tumors. CGP-45688 inhibits the growth of estrogen-dependent breast tumors in rat models. CGP-45688 disrupts the ovarian cycle and inhibits the weight of the uterus. CGP-45688 can be used for the study of breast cancer[1].
CAS Number
134520-88-0
UNSPSC
12352005
Target
Cytochrome P450
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
N#CC1=CC=C(C(C2=CC=C(C=C2)C#N)N3N=CN=N3)C=C1
Molecular Formula
C16H10N6
Molecular Weight
286.29
References & Citations
[1]Schieweck K, et al. Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen-dependent rat mammary tumors. J Steroid Biochem Mol Biol. 1993 Mar;44 (4-6) :633-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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