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MitoBloCK-1

CAT: 0804-HY-122658-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122658-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MitoBloCK-1 is an inhibitor that blocks the import of substrates that use the TIM22 import pathway. MitoBloCK-1 inhibits import by preventing binding of substrate to tim9/10 complex to the substrate, thus the substrate failed to be reach the TIM22 translocon. MitoBloCK-1 inhibits protein import of TIM22 substrates into mitochondria. MitoBloCK-1 attenuates the import of the carrier proteins including the ADP/ATP and phosphate carriers. MitoBloCK-1 also inhibits the import of an additional carrier protein, PiC, and the outer membrane protein Tom40[1][2].
CAS Number
373370-73-1
Product Name Alternative
MB-1
UNSPSC
12352005
Target
Mitochondrial Metabolism
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Purity
98.87
Smiles
S=C(N/N=C/C1=C2C(CCCC3)=C3OC2=CC(Br)=C1O)N
Molecular Formula
C14H14BrN3O2S
Molecular Weight
368.25
References & Citations
[1]Wijaya J. Utilizing Small Molecules to Study Mitochondrial Presequence-Degrading Protease. UCLA, 2015.|[2]Hasson SA, et al. Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation. Proc Natl Acad Sci U S A. 2010 May 25;107 (21) :9578-83.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

MitoBloCK-1
CAS Number373370-73-1
PubChem CID135446672
IUPAC Name[(E)-(3-bromo-2-hydroxy-6,7,8,9-tetrahydrodibenzofuran-1-yl)methylideneamino]thiourea
Molecular FormulaC14H14BrN3O2S
Molecular Weight368.25
XLogP3.2
Topological Polar Surface Area116
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity436
SMILES
C1CCC2=C(C1)C3=C(C(=C(C=C3O2)Br)O)/C=N/NC(=S)N
InChI
InChI=1S/C14H14BrN3O2S/c15-9-5-11-12(7-3-1-2-4-10(7)20-11)8(13(9)19)6-17-18-14(16)21/h5-6,19H,1-4H2,(H3,16,18,21)/b17-6+
InChIKey
VBDLLTJWFFBEAG-UBKPWBPPSA-N
Chemical Structure
2D Structure
2D structure of MitoBloCK-1
CAS: 373370-73-1
CID: 135446672
Formula: C14H14BrN3O2S
MW: 368.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight368.25
XLogP33.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass366.99901
Monoisotopic Mass366.99901
Topological Polar Surface Area116 Ų
Heavy Atom Count21
Formal Charge0
Complexity436
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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