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MitoBloCK-1

CAT: 0804-HY-122658-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-122658-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MitoBloCK-1 is an inhibitor that blocks the import of substrates that use the TIM22 import pathway. MitoBloCK-1 inhibits import by preventing binding of substrate to tim9/10 complex to the substrate, thus the substrate failed to be reach the TIM22 translocon. MitoBloCK-1 inhibits protein import of TIM22 substrates into mitochondria. MitoBloCK-1 attenuates the import of the carrier proteins including the ADP/ATP and phosphate carriers. MitoBloCK-1 also inhibits the import of an additional carrier protein, PiC, and the outer membrane protein Tom40[1][2].
CAS Number
[373370-73-1]
Product Name Alternative
MB-1
UNSPSC
12352005
Target
Mitochondrial Metabolism
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Purity
98.87
Smiles
S=C(N/N=C/C1=C2C(CCCC3)=C3OC2=CC(Br)=C1O)N
Molecular Formula
C14H14BrN3O2S
Molecular Weight
368.25
References & Citations
[1]Wijaya J. Utilizing Small Molecules to Study Mitochondrial Presequence-Degrading Protease. UCLA, 2015.|[2]Hasson SA, et al. Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation. Proc Natl Acad Sci U S A. 2010 May 25;107 (21) :9578-83.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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