MitoBloCK-1

• Description :

  MitoBloCK-1 is an inhibitor that blocks the import of substrates that use the TIM22 import pathway. MitoBloCK-1 inhibits import by preventing binding of substrate to tim9/10 complex to the substrate, thus the substrate failed to be reach the TIM22 translocon. MitoBloCK-1 inhibits protein import of TIM22 substrates into mitochondria. MitoBloCK-1 attenuates the import of the carrier proteins including the ADP/ATP and phosphate carriers. MitoBloCK-1 also inhibits the import of an additional carrier protein, PiC, and the outer membrane protein Tom40[1][2].

• Product Name Alternative :

  MB-1

• UNSPSC :

  12352005

• Target :

  Mitochondrial Metabolism

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Metabolic Disease

• Purity :

  98.87

• Smiles :

  S=C(N/N=C/C1=C2C(CCCC3)=C3OC2=CC(Br)=C1O)N

• Molecular Formula :

  C14H14BrN3O2S

• Molecular Weight :

  368.25

• References & Citations :

  [1]Wijaya J. Utilizing Small Molecules to Study Mitochondrial Presequence-Degrading Protease. UCLA, 2015.|[2]Hasson SA, et al. Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation. Proc Natl Acad Sci U S A. 2010 May 25;107 (21) :9578-83.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [373370-73-1]