MitoBloCK-12

• Background:

  Attenuates mitochondrial protein import (4-10 M) . Discovered in a screen of FDA-approved drugs. Blocks translocation of a mutant form of alanine: glyoxylate aminotransferase (AGT) to the mitochondria and restores AGT trafficking to peroxisomes.1 Also reduces oxalate accumulation and thus has potential to treat patients with primary hyperoxaluria 1 who possess mutations in AGT.1 Also displays antimicrobial activity2, inhibits apamin-sensitive K+ channels3 and induces apoptosis by inhibiting XIAP4.

• Conjugation:

  Unconjugated

• Buffer:

  Beige solid

• Storage Conditions:

  RT