PF-04308515

• Description:

  PF-04308515 is a glucocorticoid receptor ligand. PF-04308515 inhibits IL-6, IFNγ production. PF-04308515 induces weak PGC1α interaction. PF-04308515 has antiinflammatory activities[1].

• Product Name Alternative:

  PF 4308515

• UNSPSC:

  12352005

• Target:

  Glucocorticoid Receptor; Interleukin Related; PGC-1α

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C(C(C=C12)=CC=C2[C@]3(CC4=CC=CC=C4)C[C@@](C)(O)[C@@](C5=CC=CC=C5)(O)C[C@@]3([H])CC1=O)NC6=CC=CN=C6C

• Molecular Formula:

  C35H34N2O4

• Molecular Weight:

  546.66

• References & Citations:

  [1]Hu X, et al. The antagonists but not partial agonists of glucocorticoid receptor ligands show substantial side effect dissociation. Endocrinology. 2011 Aug;152 (8) :3123-34.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  IL-6

• CAS Number:

  [1206876-95-0]