CGP-59326

• Description:

  CGP-59326 (TRX-13) is a highly potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (IC50=0.027 μM) . CGP-59326 blocks the EGFR signaling pathwa, demonstrating highly selective inhibition of EGFR-dependent tumor cells. CGP-59326 is promising for research of cancers[1].

• Product Name Alternative:

  TRX-13

• UNSPSC:

  12352005

• Target:

  EGFR; Tyrosinase

• Related Pathways:

  JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  ClC1=CC=CC(NC2=NC=NC3=C2C(C)=C(C)N3)=C1

• Molecular Formula:

  C14H13ClN4

• Molecular Weight:

  272.73

• References & Citations:

  [1]Traxler P, et al. Strategies toward the design of novel and selective protein tyrosine kinase inhibitors. Pharmacol Ther. 1999 May-Jun;82 (2-3) :195-206.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [173458-56-5]