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PI-540

CAT: 0804-HY-10116Size: 1 EachDry Ice: NoHazardous: No
CAT#: HY-10116Size: 1 Each
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PI-540 is a bicyclic thienopyrimidine derivative and an orally active PI3K inhibitor. PI-540 has anti-cancer cell proliferation properties and high tissue distribution. PI-540 can inhibit different isoforms of PI3K, with IC50s of 10 nM (P110α), 3510 nM (P110β), 410 nM (P110δ), and 33110 nM (P110γ) . PI-540 also inhibits mTOR (IC50: 61 nM) and DNA-PK (IC50: 525 nM) [1].
CAS Number
[885616-78-4]
UNSPSC
12352005
Target
MTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi-540.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=CC(C2=NC(N3CCOCC3)=C(SC(CN4CCN(C)CC4)=C5)C5=N2)=C1
Molecular Formula
C22H27N5O2S
Molecular Weight
425.55
References & Citations
[1]Raynaud FI, et al. Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941. Mol Cancer Ther. 2009 Jul;8 (7) :1725-38.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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