BLX-2477

• Description:

  BLX-2477 is a potent and selective 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 99 nM. BLX-2477 can inhibit the generation of inflammatory lipid mediators such as 15-hydroxy-eicosatetraenoic acid (15-HETE) . BLX-2477 can be used for the research of inflammation and immunology[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Lipoxygenase

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C (C1=NNN=C1) NC2=CC=C (Cl) C=C2Cl

• Molecular Formula:

  C9H6Cl2N4O

• Molecular Weight:

  257.08

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Pelcman B, et al. 3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1. Bioorg Med Chem Lett. 2015 Aug 1;25 (15) :3024-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound2

• Clinical Information:

  No Development Reported

• Isoform:

  15-LOX

• CAS Number:

  1080008-87-2