BLX-2477

CAT: 0804-HY-117317Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117317Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BLX-2477 is a potent and selective 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 99 nM. BLX-2477 can inhibit the generation of inflammatory lipid mediators such as 15-hydroxy-eicosatetraenoic acid (15-HETE) . BLX-2477 can be used for the research of inflammation and immunology[1].
CAS Number
[1080008-87-2]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Lipoxygenase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=NNN=C1)NC2=CC=C(Cl)C=C2Cl
Molecular Formula
C9H6Cl2N4O
Molecular Weight
257.08
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Pelcman B, et al. 3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1. Bioorg Med Chem Lett. 2015 Aug 1;25 (15) :3024-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
15-LOX

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