BLX-2477

• Description :

  BLX-2477 is a potent and selective 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 99 nM. BLX-2477 can inhibit the generation of inflammatory lipid mediators such as 15-hydroxy-eicosatetraenoic acid (15-HETE) . BLX-2477 can be used for the research of inflammation and immunology[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Lipoxygenase

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C(C1=NNN=C1)NC2=CC=C(Cl)C=C2Cl

• Molecular Formula :

  C9H6Cl2N4O

• Molecular Weight :

  257.08

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Pelcman B, et al. 3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1. Bioorg Med Chem Lett. 2015 Aug 1;25 (15) :3024-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound2

• Clinical Information :

  No Development Reported

• Isoform :

  15-LOX

• CAS Number :

  [1080008-87-2]