S-2474

• Description :

  S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC50s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory agent.

• UNSPSC :

  12352005

• Target :

  COX; Lipoxygenase

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/S-2474.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=C(C(C)(C)C)C=C(/C=C2CCN(CC)S\2(=O)=O)C=C1C(C)(C)C

• Molecular Formula :

  C20H31NO3S

• Molecular Weight :

  365.53

• References & Citations :

  [1]Yagami T, et al. Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid beta protein-induced neuronal cell death. Br J Pharmacol. 2001 Oct;134 (3) :673-81.|[2]Yagami T, et al. S-2474, a novel nonsteroidal anti-inflammatory drug, rescues cortical neurons from human group IIA secretory phospholipase A (2) -induced apoptosis. Neuropharmacology. 2005 Aug;49 (2) :174-84. Epub 2005 Apr 1.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  5-LOX; COX-1; COX-2

• CAS Number :

  [158089-95-3]