SAMT-247

• Description :

  SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. SAMT-247 shows good antiviral activity[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  HIV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/samt-247.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(SC1=CC=CC=C1C(NCCC(N)=O)=O)=O

• Molecular Formula :

  C12H14N2O3S

• Molecular Weight :

  266.32

• Precautions :

  H302

• References & Citations :

  [1]Helmold Hait S, et al. An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes. J Immunol. 2020 Jun 15;204 (12) :3315-3328.|[2]Miller Jenkins LM, et al. Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer. Nat Chem Biol. 2010 Dec;6 (12) :887-9.|[3]Cheng-Mayer C, et al. Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide. AIDS. 2011 Sep 24;25 (15) :1833-41.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HIV-1

• CAS Number :

  [850715-59-2]