Sch-40338

• Description :

  Sch-40338 is a dual antagonist of platelet-activating factor (PAF) and histamine with an IC50 of 0.59 μM (PAF-induced platelet aggregation) and a Ki of 5.4 μM (Histamine H₁ receptor binding) . Sch-40338 can be used for the study of allergic disease[1].

• UNSPSC :

  12352005

• Target :

  Histamine Receptor; Platelet-activating Factor Receptor (PAFR)

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Smiles :

  CC(N1CCN(CC1)C2C3=CC=C(C=C3CCC4=CC=CN=C24)Cl)=O

• Molecular Formula :

  C20H22ClN3O

• Molecular Weight :

  355.86

• References & Citations :

  [1]Kaminski JJ, et al. Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. Bioorg Med Chem. 1999 Jul;7 (7) :1413-23.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [117796-62-0]