UK 343664

CAT: 0804-HY-105341Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-105341Size:1 Each
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Description
UK 343664 is a potent, orally active and selective PDE5 inhibitor. UK 343664 partially reverses Thromboxane-induced pulmonary hypertension[1][2].
CAS Number
[215297-27-1]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
O=C1N=C(C2=C(OCCC)C=CC(S(=O)(N3CCN(CC3)CC)=O)=C2)NC4=C(CC)N(CC5=NC=CC=C5)N=C41
Molecular Formula
C28H35N7O4S
Molecular Weight
565.69
References & Citations
[1]Walker DK, et al. Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog. Xenobiotica. 2001 Aug-Sep;31 (8-9) :651-64. |[2]Urdaneta F, et al. Effects of a new phosphodiesterase enzyme type V inhibitor (UK 343-664) versus milrinone in a porcine model of acute pulmonary hypertension. Ann Thorac Surg. 2004 Oct;78 (4) :1433-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE5

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