Amg-1

• Description:

  Amg-1 is a potent, reversible and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor (IC50 = 3.0 μM) . Amg-1 exhibits >80-fold selectivity over IDO2 (IC50 > 250 μM) and >20-fold selective over TDO (IC50 > 62.5 μM) . Amg-1 can be used for cancer, hypotension, and neurological disorders research[1].

• UNSPSC:

  12352005

• Target:

  Indoleamine 2,3-Dioxygenase (IDO)

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Cardiovascular Disease; Neurological Disease

• Purity:

  99.9

• Smiles:

  O=C(NC1=CC=C(OCO2)C2=C1)CSC3=NN=C4N3C(C5=CC=C(C)C=C5)=CS4

• Molecular Formula:

  C20H16N4O3S2

• Molecular Weight:

  424.50

• References & Citations:

  [1]Meininger D, et al. Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors. Biochim Biophys Acta. 2011 Dec;1814 (12) :1947-54.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  IDO1; IDO2

• CAS Number:

  496023-55-3