Amg-1

• Description :

  Amg-1 is a potent, reversible and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor (IC50 = 3.0 μM) . Amg-1 exhibits >80-fold selectivity over IDO2 (IC50 > 250 μM) and >20-fold selective over TDO (IC50 > 62.5 μM) . Amg-1 can be used for cancer, hypotension, and neurological disorders research[1].

• UNSPSC :

  12352005

• Target :

  Indoleamine 2,3-Dioxygenase (IDO)

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Cardiovascular Disease; Neurological Disease

• Purity :

  99.9

• Smiles :

  O=C(NC1=CC=C(OCO2)C2=C1)CSC3=NN=C4N3C(C5=CC=C(C)C=C5)=CS4

• Molecular Formula :

  C20H16N4O3S2

• Molecular Weight :

  424.50

• References & Citations :

  [1]Meininger D, et al. Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors. Biochim Biophys Acta. 2011 Dec;1814 (12) :1947-54.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IDO1; IDO2

• CAS Number :

  [496023-55-3]