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Amg-1

CAT: 0804-HY-112867-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112867-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amg-1 is a potent, reversible and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor (IC50 = 3.0 μM) . Amg-1 exhibits >80-fold selectivity over IDO2 (IC50 > 250 μM) and >20-fold selective over TDO (IC50 > 62.5 μM) . Amg-1 can be used for cancer, hypotension, and neurological disorders research[1].
CAS Number
496023-55-3
UNSPSC
12352005
Target
Indoleamine 2,3-Dioxygenase (IDO)
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease; Neurological Disease
Purity
99.9
Smiles
O=C(NC1=CC=C(OCO2)C2=C1)CSC3=NN=C4N3C(C5=CC=C(C)C=C5)=CS4
Molecular Formula
C20H16N4O3S2
Molecular Weight
424.50
References & Citations
[1]Meininger D, et al. Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors. Biochim Biophys Acta. 2011 Dec;1814 (12) :1947-54.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDO1; IDO2

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