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DOTAP (chloride) (GMP Like)

CAT: 0804-HY-112754AGL-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112754AGL-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DOTAP chloride (GMP Like) is the GMP Like class DOTAP chloride. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAP chloride is a cationic lipid with good membrane fusion ability and biocompatibility. DOTAP chloride (GMP Like) can be used as an excipient for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) without the use of helper lipid[1].
CAS Number
132172-61-3
Product Name Alternative
1,2-Dioleoyl-3-trimethylammonium-propane (chloride) (GMP Like)
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Liposome
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Smiles
CCCCCCCC/C=C\CCCCCCCC(OCC(OC(CCCCCCC/C=C\CCCCCCCC)=O)C[N+](C)(C)C)=O.[Cl-]
Molecular Formula
C42H80ClNO4
Molecular Weight
698.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim BK, et al. DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes.Biochim Biophys Acta. 2015 Oct;1848 (10 Pt A) :1996-2001.
Shipping Conditions
Blue Ice
Storage Conditions
Kept at -20 ± 5°C under an inert atmosphere.
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported

Chemical Information

Dotap chloride
CAS Number132172-61-3
PubChem CID11636182
IUPAC Name2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium chloride
Molecular FormulaC42H80ClNO4
Molecular Weight698.5
Topological Polar Surface Area52.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count37
Heavy Atom Count48
Formal Charge0
Complexity754
SMILES
CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC.[Cl-]
InChI
InChI=1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;
InChIKey
KSXTUUUQYQYKCR-LQDDAWAPSA-M
Chemical Structure
2D Structure
2D structure of Dotap chloride
CAS: 132172-61-3
CID: 11636182
Formula: C42H80ClNO4
MW: 698.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight698.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count37
Exact Mass697.5775877
Monoisotopic Mass697.5775877
Topological Polar Surface Area52.6 Ų
Heavy Atom Count48
Formal Charge0
Complexity754
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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