DOTAP (chloride)

• UNSPSC Description:

  DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid[1].

• Target Antigen:

  Liposome

• Type:

  Oligonucleotides

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dotap-chloride.html

• Purity:

  98.0

• Solubility:

  DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : 130 mg/mL (ultrasonic)

• Smiles:

  CCCCCCCC/C=C\CCCCCCCC(OCC(OC(CCCCCCC/C=C\CCCCCCCC)=O)C[N+](C)(C)C)=O.[Cl-]

• Molecular Weight:

  698.54

• References & Citations:

  [1]Kim BK, et al. DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes.Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):1996-2001.Adv Healthc Mater. 2022: 2202412.|Exploration. 2024 Jun 26.|Nanoscale. 2023 Nov 16;15(44):17825-17838.|Pharmaceutics. 2023 Apr 30, 15(5), 1379.|SSRN. 2024 Nov 12.|Drug Dev Ind Pharm. 2024 Aug 7:1-16.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Clinical Information:

  Phase 2

• CAS Number:

  132172-61-3