DOTAP (chloride)

• Description :

  DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid[1].

• Product Name Alternative :

  1,2-Dioleoyl-3-trimethylammonium-propane (chloride)

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Liposome

• Type :

  Oligonucleotides

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dotap-chloride.html

• Purity :

  99.91

• Solubility :

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 130 mg/mL (ultrasonic)

• Smiles :

  CCCCCCCC/C=C\CCCCCCCC(OCC(OC(CCCCCCC/C=C\CCCCCCCC)=O)C[N+](C)(C)C)=O.[Cl-]

• Molecular Formula :

  C42H80ClNO4

• Molecular Weight :

  698.54

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kim BK, et al. DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes.Biochim Biophys Acta. 2015 Oct;1848 (10 Pt A) :1996-2001.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Oligonucleotides

• Clinical Information :

  Phase 2

• Citation 01 :

  Adv Healthc Mater. 2023 Jan;12 (6) :e2202412.|bioRxiv. 2025 Oct 1.|Exploration. 2024 Jun 26;5 (1) :20240002.|Microbiol Spectr. 2025 Nov 5;13 (12) :e0143825.|Nanoscale. 2023 Nov 16;15 (44) :17825-17838.|Nat Immunol. 2025 Oct;26 (10) :1660-1672.|Pharmaceutics. 2023 Apr 30;15 (5) :1379.|SSRN. 2024 Nov 12.|University of Washington. 2025.|Drug Dev Ind Pharm. 2024 Aug 7:1-16.|Signal Transduct Target Ther. 2025 Mar 24;10 (1) :101.

• CAS Number :

  [132172-61-3]