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Dasatinib (GMP Like)

CAT: 0804-HY-10181GLSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10181GLSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dasatinib (GMP Like) (BMS-354825 (GMP Like) ) is Dasatinib produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC50s of. Dasatinib also induces apoptosis and autophagy.
CAS Number
302962-49-8
Product Name Alternative
BMS-354825 (GMP Like)
UNSPSC
12352005
Target
Apoptosis; Autophagy; Bcr-Abl; Src
Related Pathways
Apoptosis; Autophagy; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C1=CN=C(S1)NC2=NC(C)=NC(N3CCN(CC3)CCO)=C2)NC4=C(C=CC=C4Cl)C
Molecular Formula
C22H26ClN7O2S
Molecular Weight
488.01
References & Citations
[1]Lombardo LJ, et al. Discovery of N- (2-chloro-6-methyl- phenyl) -2- (6- (4- (2-hydroxyethyl) - piperazin-1-yl) -2-methylpyrimidin-4- ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004 Dec 30;47 (27) :6658-61.
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported

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586926-01Insulin-like Growth Factor-1, Active, Recombinant, Human, aa49-118 (IGF1) (GMP)
168531SUMO (Small Ubiquitin-like Modifier, GAP modifying protein 1, GMP 1, PIC 1, Sentrin, Small ubiquitin related modifier 1)
353242CD62P (Antigen CD62, CD62 Antigen Like Family Member P, CD62P Antigen, GMP 140, GMP140, GMP-140, GMRP, GRMP, Granule Membrane Protein 140, Granule Membrane Protein 140kD, LECAM 3, LECAM3, LYAM3, P Selectin, PADGEM, PSelectin, P-Selectin, Selectin P)
C2548-89LP-Selectin (SELP, CD62 antigen-like family member P, Granule membrane protein 140, GMP-140, Leukocyte-endothelial cell adhesion molecule 3, LECAM3, PADGEM, CD-antigen: CD62P) discontinued
397547Selp (P-Selectin, CD62 Antigen-Like Family Member P, Granule Membrane Protein 140, GMP-140, Leukocyte-Endothelial Cell Adhesion Molecule 3, LECAM3, Platelet Activation Dependent Granule-External Membrane Protein, PADGEM, CD62P, Grmp)
C2415-55ZCD62P (P-Selectin, CD62 Antigen-like Family Member P, Granule Membrane Protein 140, GMP-140, Leukocyte-endothelial Cell Adhesion Molecule 3, LECAM3, Platelet Activation Dependent Granule-external Membrane Protein, PADGEM, SELP, GMRP, GRMP)
124666-HRPCD62P (P-Selectin, CD62 Antigen-like Family Member P, Granule Membrane Protein 140, GMP-140, Leukocyte-endothelial Cell Adhesion Molecule 3, LECAM3, Platelet Activation Dependent Granule-external Membrane Protein, PADGEM, SELP, GMRP, GRMP) (HRP)
124666-APCCD62P (P-Selectin, CD62 Antigen-like Family Member P, Granule Membrane Protein 140, GMP-140, Leukocyte-endothelial Cell Adhesion Molecule 3, LECAM3, Platelet Activation Dependent Granule-external Membrane Protein, PADGEM, SELP, GMRP, GRMP) (APC)

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