Nicotinamide (GMP Like)

CAT: 0804-HY-B0150GLSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B0150GLSize:1 Each
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Description
Nicotinamide (GMP Like) (Niacinamide (GMP Like) ) is Nicotinamide (HY-B0150) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM) . Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity[1][2][3][4].
CAS Number
[98-92-0]
Product Name Alternative
Niacinamide (GMP Like) ; Nicotinic acid amide (GMP Like)
UNSPSC
12352005
Target
Endogenous Metabolite; HBV; Sirtuin
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer; Infection
Smiles
O=C(C1=CC=CN=C1)N
Molecular Formula
C6H6N2O
Molecular Weight
122.12
References & Citations
[1]Francesca Scatozza, et al. Nicotinamide inhibits melanoma in vitro and in vivo. J Exp Clin Cancer Res. 2020 Oct 7;39 (1) :211.|[2]Hwang ES, et al. Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells. Cell Mol Life Sci. 2017 Sep;74 (18) :3347-3362. |[3]Li WY, et al. The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo. Arch Virol. 2016 Mar;161 (3) :621-30. |[4]Zhang Y, et al. Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells. Stem Cell Res Ther. 2021 Jun 25;12 (1) :362.
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported

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Alternative Products

CatalogName
HEGFP-0906Recombinant Human Insulin-like Growth factor-1 GMP
P1445-.1Recombinant Human Neuregulin 1-beta2 EGF-like domain GMP
586926-01Insulin-like Growth Factor-1, Active, Recombinant, Human, aa49-118 (IGF1) (GMP)
168531SUMO (Small Ubiquitin-like Modifier, GAP modifying protein 1, GMP 1, PIC 1, Sentrin, Small ubiquitin related modifier 1)
353242CD62P (Antigen CD62, CD62 Antigen Like Family Member P, CD62P Antigen, GMP 140, GMP140, GMP-140, GMRP, GRMP, Granule Membrane Protein 140, Granule Membrane Protein 140kD, LECAM 3, LECAM3, LYAM3, P Selectin, PADGEM, PSelectin, P-Selectin, Selectin P)
362899DUOX2 (Dual Oxidase 2, LNOX2, NOXEF2, THOX2, Thyroid oxidase 2, NADH/NADPH thyroid oxidase p138-tox, Dual Oxidase-Like Domains 2, Nicotinamide Adenine Dinucleotide Phosphate Oxidase)
C2548-89LP-Selectin (SELP, CD62 antigen-like family member P, Granule membrane protein 140, GMP-140, Leukocyte-endothelial cell adhesion molecule 3, LECAM3, PADGEM, CD-antigen: CD62P) discontinued
397547Selp (P-Selectin, CD62 Antigen-Like Family Member P, Granule Membrane Protein 140, GMP-140, Leukocyte-Endothelial Cell Adhesion Molecule 3, LECAM3, Platelet Activation Dependent Granule-External Membrane Protein, PADGEM, CD62P, Grmp)
C2415-55ZCD62P (P-Selectin, CD62 Antigen-like Family Member P, Granule Membrane Protein 140, GMP-140, Leukocyte-endothelial Cell Adhesion Molecule 3, LECAM3, Platelet Activation Dependent Granule-external Membrane Protein, PADGEM, SELP, GMRP, GRMP)
124666-HRPCD62P (P-Selectin, CD62 Antigen-like Family Member P, Granule Membrane Protein 140, GMP-140, Leukocyte-endothelial Cell Adhesion Molecule 3, LECAM3, Platelet Activation Dependent Granule-external Membrane Protein, PADGEM, SELP, GMRP, GRMP) (HRP)

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