AX-024

CAT: 0931-MF-0049330-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0049330-01Size:2 mg
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
1370544-73-2
Target
Others|||Interleukin|||TNF|||IFNAR
Related Pathways
Others|||Immunology/Inflammation|||Apoptosis
Bioactivity
AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. With an IC50 value of approximately 1 nM, AX-024 effectively modulates cell signaling by specifically targeting SH3 domains. Additionally, AX-024 demonstrates desirable characteristics such as low acute toxicity, high potency, and excellent selectivity. Notably, it exhibits strong inhibitory effects on the production of IL-6, TNF-?, IFN-?, IL-10, and IL-17A.
Smiles
COc1ccc2OCC(CN3CCCC3)=C(c3ccc(F)cc3)c2c1
Molecular Formula
C21H22FNO2
Molecular Weight
339.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Popular Products