AX-024

CAT: 0931-T61071-01Size: 2 mgDry Ice: NoHazardous: No

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CAT#:0931-T61071-01Size:2 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1370544-73-2

Target

Others, Interleukin, TNF, IFNAR

Related Pathways

Others, Immunology/Inflammation, Apoptosis

Bioactivity

AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. With an IC50 value of approximately 1 nM, AX-024 effectively modulates cell signaling by specifically targeting SH3 domains. Additionally, AX-024 demonstrates desirable characteristics such as low acute toxicity, high potency, and excellent selectivity. Notably, it exhibits strong inhibitory effects on the production of IL-6, TNF-α, IFN-γ, IL-10, and IL-17A.

Smiles

COc1ccc2OCC(CN3CCCC3)=C(c3ccc(F)cc3)c2c1

Molecular Formula

C21H22FNO2

Molecular Weight

339.4

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
VEC54473-01	AX-024
S6727-2mg	AX-024 HCl
A16926-50	AX-024 50mg
B2013-5	AX-024 hydrochloride
A16926-100	AX-024 100mg
A16926-25	AX-024 25mg
A16926-10	AX-024 10mg
A16926-5	AX-024 5mg
A16926-2	AX-024 2mg

AX-024

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