AX-024

• Target:

  Others|||Interleukin|||TNF|||IFNAR

• Related Pathways:

  Others|||Immunology/Inflammation|||Apoptosis

• Bioactivity:

  AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. With an IC50 value of approximately 1 nM, AX-024 effectively modulates cell signaling by specifically targeting SH3 domains. Additionally, AX-024 demonstrates desirable characteristics such as low acute toxicity, high potency, and excellent selectivity. Notably, it exhibits strong inhibitory effects on the production of IL-6, TNF-?, IFN-?, IL-10, and IL-17A.

• Smiles:

  COc1ccc2OCC(CN3CCCC3)=C(c3ccc(F)cc3)c2c1

• Molecular Formula:

  C21H22FNO2

• Molecular Weight:

  339.4

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1370544-73-2