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AX-024

CAT: 0931-T61071-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T61071-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1370544-73-2
Target
Others, Interleukin, TNF, IFNAR
Related Pathways
Others, Immunology/Inflammation, Apoptosis
Bioactivity
AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. With an IC50 value of approximately 1 nM, AX-024 effectively modulates cell signaling by specifically targeting SH3 domains. Additionally, AX-024 demonstrates desirable characteristics such as low acute toxicity, high potency, and excellent selectivity. Notably, it exhibits strong inhibitory effects on the production of IL-6, TNF-α, IFN-γ, IL-10, and IL-17A.
Smiles
COc1ccc2OCC(CN3CCCC3)=C(c3ccc(F)cc3)c2c1
Molecular Formula
C21H22FNO2
Molecular Weight
339.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

AX-024
CAS Number1370544-73-2
PubChem CID56949412
IUPAC Name1-[[4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl]methyl]pyrrolidine
Molecular FormulaC21H22FNO2
Molecular Weight339.4
XLogP3.4
Topological Polar Surface Area21.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity480
SMILES
COC1=CC2=C(C=C1)OCC(=C2C3=CC=C(C=C3)F)CN4CCCC4
InChI
InChI=1S/C21H22FNO2/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23/h4-9,12H,2-3,10-11,13-14H2,1H3
InChIKey
VMMKGVRPILDZML-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of AX-024
CAS: 1370544-73-2
CID: 56949412
Formula: C21H22FNO2
MW: 339.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight339.4
XLogP33.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass339.16345711
Monoisotopic Mass339.16345711
Topological Polar Surface Area21.7 Ų
Heavy Atom Count25
Formal Charge0
Complexity480
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
VEC54473-01AX-024
S6727-2mgAX-024 HCl
A16926-50AX-024 50mg
B2013-5AX-024 hydrochloride
A16926-100AX-024 100mg
A16926-25AX-024 25mg
A16926-10AX-024 10mg
A16926-5AX-024 5mg
A16926-2AX-024 2mg

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