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NBI-31772 (Standard)

CAT: 0804-HY-110135R-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110135R-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NBI-31772 (Standard) is the analytical standard of NBI-31772. This product is intended for research and analytical applications. NBI-31772 is a non-selective IGFBP inhibitor (Ki=47 nM) . NBI-31772 has neuroprotective effects and reduces infarct volume during cerebral ischemia. NBI-31772 can also restore or enhance proteoglycan synthesis in osteoarticular chondrocytes. In addition, NBI-31772 also increases the effect of IGF3 on zebrafish oocyte maturation[1][2][3][4].
CAS Number
374620-70-9
UNSPSC
12352100
Target
IGF-1R; Reference Standards
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(C1=CC(O)=C(O)C=C1)C2=NC(C(O)=O)=CC3=C2C=C(O)C(O)=C3
Molecular Formula
C17H11NO7
Molecular Weight
341.27
References & Citations
[1]Khawaja XZ. Development of a scintillation proximity assay for human insulin-like growth factor-binding protein 4 compatible with inhibitor high-throughput screening. Anal Biochem. 2007;366 (1) :80-86.|[2]Mackay K B, et al. Neuroprotective effects of insulin-like growth factor-binding protein ligand inhibitors in vitro and in vivo[J]. Journal of Cerebral Blood Flow & Metabolism, 2003, 23 (10) : 1160-1167.|[3]De Ceuninck F, et al. Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes[J]. Arthritis Res Ther, 2004, 6: 1-11.|[4]Li J, et al. Insulin-like growth factor binding proteins inhibit oocyte maturation of zebrafish[J]. General and Comparative Endocrinology, 2019, 281: 83-90.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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