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Amonafide (Standard)

CAT: 0804-HY-10982R-03Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10982R-03Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amonafide (Standard) is the analytical standard of Amonafide. This product is intended for research and analytical applications. Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.
CAS Number
69408-81-7
UNSPSC
12352100
Target
Reference Standards; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
O=C1N(C(C2=CC(N)=CC3=CC=CC1=C23)=O)CCN(C)C
Molecular Formula
C16H17N3O2
Molecular Weight
283.33
References & Citations
[1]Allen SL, et al. Amonafide: a potential role in treating acute myeloid leukemia. Expert Opin Investig Drugs. 2011 Jul;20 (7) :995-1003.|[2]Andersson BS, et al. In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia. Cancer Res. 1987 Feb 15;47 (4) :1040-4.|[3]Ajani JA, et al. In vitro activity of amonafide against primary human tumors compared with the activity of standard agents. Invest New Drugs. 1988 Jun;6 (2) :79-85.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Amonafide

5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione is a member of isoquinolines.

CAS Number69408-81-7
PubChem CID50515
IUPAC Name5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione
Molecular FormulaC16H17N3O2
Molecular Weight283.32
XLogP1.5
Topological Polar Surface Area66.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity437
SMILES
CN(C)CCN1C(=O)C2=CC=CC3=CC(=CC(=C32)C1=O)N
InChI
InChI=1S/C16H17N3O2/c1-18(2)6-7-19-15(20)12-5-3-4-10-8-11(17)9-13(14(10)12)16(19)21/h3-5,8-9H,6-7,17H2,1-2H3
InChIKey
UPALIKSFLSVKIS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Amonafide
CAS: 69408-81-7
CID: 50515
Formula: C16H17N3O2
MW: 283.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight283.32
XLogP31.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass283.132076794
Monoisotopic Mass283.132076794
Topological Polar Surface Area66.6 Ų
Heavy Atom Count21
Formal Charge0
Complexity437
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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