Amonafide (Standard)

• Description :

  Amonafide (Standard) is the analytical standard of Amonafide. This product is intended for research and analytical applications. Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.

• CAS Number :

  [69408-81-7]

• UNSPSC :

  12352100

• Target :

  Reference Standards; Topoisomerase

• Related Pathways :

  Cell Cycle/DNA Damage; Others

• Field of Research :

  Cancer

• Smiles :

  O=C1N(C(C2=CC(N)=CC3=CC=CC1=C23)=O)CCN(C)C

• Molecular Formula :

  C16H17N3O2

• Molecular Weight :

  283.33

• References & Citations :

  [1]Allen SL, et al. Amonafide: a potential role in treating acute myeloid leukemia. Expert Opin Investig Drugs. 2011 Jul;20 (7) :995-1003.|[2]Andersson BS, et al. In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia. Cancer Res. 1987 Feb 15;47 (4) :1040-4.|[3]Ajani JA, et al. In vitro activity of amonafide against primary human tumors compared with the activity of standard agents. Invest New Drugs. 1988 Jun;6 (2) :79-85.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards