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Amonafide (Standard)

CAT: 0804-HY-10982R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10982R-01Size:5 mg
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Description
Amonafide (Standard) is the analytical standard of Amonafide. This product is intended for research and analytical applications. Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.
CAS Number
[69408-81-7]
UNSPSC
12352100
Target
Reference Standards; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
O=C1N(C(C2=CC(N)=CC3=CC=CC1=C23)=O)CCN(C)C
Molecular Formula
C16H17N3O2
Molecular Weight
283.33
References & Citations
[1]Allen SL, et al. Amonafide: a potential role in treating acute myeloid leukemia. Expert Opin Investig Drugs. 2011 Jul;20 (7) :995-1003.|[2]Andersson BS, et al. In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia. Cancer Res. 1987 Feb 15;47 (4) :1040-4.|[3]Ajani JA, et al. In vitro activity of amonafide against primary human tumors compared with the activity of standard agents. Invest New Drugs. 1988 Jun;6 (2) :79-85.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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