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Amonafide (dihydrochloride)

CAT: 0804-HY-10982ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10982ASize:1 Each
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Description
Amonafide dihydrochloride (AS1413 dihydrochloride) is a topoisomerase II (Topo II) inhibitor and DNA intercalator with activity in inducing apoptotic signaling. Amonafide dihydrochloride can inhibit the binding of Topo II to DNA, thereby preventing the synthesis of DNA and RNA. Amonafide dihydrochloride maintains cytotoxic activity in the presence of P-glycoprotein-mediated multidrug resistance (MDR) [1].
CAS Number
150091-68-2
Product Name Alternative
AS1413 (dihydrochloride)
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/amonafide-dihydrochloride.html
Smiles
O=C1N(C(C2=CC(N)=CC3=CC=CC1=C23)=O)CCN(C)C.Cl.Cl
Molecular Formula
C16H19Cl2N3O2
Molecular Weight
356.25
References & Citations
[1]Amonafide: a potential role in treating acute myeloid leukemia
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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