Pepstatin (Standard)

• Description :

  Pepstatin (Standard) is the analytical standard of Pepstatin. This product is intended for research and analytical applications. Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease[1][2].

• CAS Number :

  [26305-03-3]

• Product Name Alternative :

  Pepstatin A (Standard)

• UNSPSC :

  12352209

• Target :

  Autophagy; HIV Protease; Reference Standards

• Related Pathways :

  Anti-infection; Autophagy; Metabolic Enzyme/Protease; Others

• Field of Research :

  Infection; Inflammation/Immunology

• Smiles :

  CC(C[C@H](NC([C@@H](NC([C@@H](NC(CC(C)C)=O)C(C)C)=O)C(C)C)=O)[C@@H](O)CC(N[C@@H](C)C(N[C@@H](CC(C)C)[C@@H](O)CC(O)=O)=O)=O)C

• Molecular Formula :

  C34H63N5O9

• Molecular Weight :

  685.89

• References & Citations :

  [1]Umezawa H, et al. Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo) . 1970 May;23 (5) :259-62.|[2]Seelmeier S, et al. Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A. Proc Natl Acad Sci U S A. 1988 Sep;85 (18) :6612-6.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards