Products for Research Use Only

Pepstatin (Standard)

CAT: 0804-HY-P0018R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0018R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pepstatin (Standard) is the analytical standard of Pepstatin. This product is intended for research and analytical applications. Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease[1][2].
CAS Number
26305-03-3
Product Name Alternative
Pepstatin A (Standard)
UNSPSC
12352209
Target
Autophagy; HIV Protease; Reference Standards
Related Pathways
Anti-infection; Autophagy; Metabolic Enzyme/Protease; Others
Field of Research
Infection; Inflammation/Immunology
Smiles
CC(C[C@H](NC([C@@H](NC([C@@H](NC(CC(C)C)=O)C(C)C)=O)C(C)C)=O)[C@@H](O)CC(N[C@@H](C)C(N[C@@H](CC(C)C)[C@@H](O)CC(O)=O)=O)=O)C
Molecular Formula
C34H63N5O9
Molecular Weight
685.89
References & Citations
[1]Umezawa H, et al. Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo) . 1970 May;23 (5) :259-62.|[2]Seelmeier S, et al. Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A. Proc Natl Acad Sci U S A. 1988 Sep;85 (18) :6612-6.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards