Amonafide

• Description :

  Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.

• Product Name Alternative :

  AS1413

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Topoisomerase

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/amonafide.html

• Purity :

  99.92

• Solubility :

  DMSO : 41.67 mg/mL (ultrasonic)

• Smiles :

  O=C1N(C(C2=CC(N)=CC3=CC=CC1=C23)=O)CCN(C)C

• Molecular Formula :

  C16H17N3O2

• Molecular Weight :

  283.33

• Precautions :

  H302

• References & Citations :

  [1]Allen SL, et al. Amonafide: a potential role in treating acute myeloid leukemia. Expert Opin Investig Drugs. 2011 Jul;20 (7) :995-1003.|[2]Andersson BS, et al. In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia. Cancer Res. 1987 Feb 15;47 (4) :1040-4.|[3]Ajani JA, et al. In vitro activity of amonafide against primary human tumors compared with the activity of standard agents. Invest New Drugs. 1988 Jun;6 (2) :79-85.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• Isoform :

  Topo II

• CAS Number :

  [69408-81-7]